WebMar 3, 2024 · TLE3 is a repressor that was found to associate with WNT/β-catenin–driven EMT . FOXA1 was shown to recruit TLE3 to specific genomic target sites to elicit … WebDec 19, 2024 · Through a genome-wide CRISPR/Cas9 screen, Palit et al. identified a transducin-like enhancer of split 3 (TLE3) as a modulator of AR inhibitor sensitivity that, upon loss, confers resistance to ...
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WebFeb 7, 2024 · USP47 interacted with TLE3 and XIAP but did not alter their amounts; however, knockdown of USP47 enhanced XIAP-mediated ubiquitylation of TLE3. USP47 inhibited … WebNov 11, 2024 · Given that TLE3/HDACs can inhibit Wnt/β-catenin signaling and that Wnt activation has adverse effects on the growth of melanoma cells, these results suggest that TLE3 might promote melanoma progression by regulating Wnt signaling ( Ogawa et al., 2024 ). fcfcoa pre-action procedures property
Frontiers Roles of transducin-like enhancer of split (TLE) family ...
WebAug 4, 2024 · We found that, via its glutamine- and serine/proline-rich domains, TLE3 interferes with MyoD function by disrupting the association between the basic helix-loop-helix domain of MyoD and E proteins. WebNov 11, 2024 · Studies in Drosophilahave found that Rdp3, a homolog of mammalian histone deacetylase 1 (HDAC1), binds to the Gro protein and inhibits target gene expression through histone deacetylation (Mannervik and Levine, 1999). Consistently, mammalian TLEs are reported to recruit different HDACs and suppress transcription in different cell contexts. WebSep 27, 2016 · TLE3 represses colorectal cancer proliferation by inhibiting MAPK and AKT signaling pathways. Run-Wei Yang Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China. Search articles by 'Run-Wei Yang' Yang RW1, Ying-Yue Zeng fcfcoa notice of intention to withdraw